The Sedative Power of Progesterone in the Luteal Phase
Obie Editorial Team
If you've ever wondered why some nights you fall asleep easily and others you're tossing and turning for hours, your hormones might be part of the answer. Your menstrual cycle influences more than your mood and physical symptoms. It also has a real, measurable impact on your sleep patterns. And one key player in this rhythm is progesterone.
Progesterone rises after ovulation during the second half of your cycle—the luteal phase. Often referred to as the "relaxation hormone," progesterone has natural sedative effects that can make you feel calmer, sleepier, or even more fatigued than usual. Understanding how this hormone interacts with your brain and body can help explain both the restful nights and the occasional insomnia that seem to follow a monthly rhythm.
Sleep is regulated by a complex interplay of brain activity, neurotransmitters, and hormones. During the luteal phase, progesterone rises sharply as the body prepares for a possible pregnancy. One of progesterone’s lesser-known effects is its influence on the GABA system, a neurotransmitter pathway that promotes relaxation and reduces neural excitability. Essentially, progesterone acts like a natural anti-anxiety agent, helping initiate and maintain sleep.
In their 2023 review, Rugvedh and colleagues discuss how hormonal fluctuations, particularly those involving estrogen and progesterone, impact not only cardiovascular function but also sleep quality throughout the cycle. They note that progesterone’s sedative effects may improve sleep duration in some individuals, though, paradoxically, its rise is also associated with increases in body temperature and potential sleep disruptions like night sweats or restlessness for others.
Even though progesterone promotes sleepiness, that doesn’t always mean your sleep is refreshing. Here’s what’s happening in the luteal phase:
Knowing that hormones are behind your shifting sleep patterns can help you adopt supportive habits instead of feeling frustrated or confused by your body’s changes. Try the following tips to make the most of progesterone’s sleep-promoting effects:
It’s easy to overlook the link between sleep and hormones, especially when life feels busy or stress levels are high. But tuning into your body’s natural cycle offers insight and a sense of control. Instead of pushing through fatigue or blaming yourself for poor sleep, you can recognize when your body is asking for extra care.
Progesterone’s calming influence is one way your body supports you in slowing down and recovering, especially in the days leading up to your period. Understanding this rhythm can make rest feel less like a luxury and more like a form of responsive self-care.
Source:
Rugvedh P, Gundreddy P, Wandile B. The Menstrual Cycle's Influence on Sleep Duration and Cardiovascular Health: A Comprehensive Review. Cureus. 2023 Oct 18;15(10):e47292. doi: 10.7759/cureus.47292. PMID: 38022155; PMCID: PMC10656370.